U.S. Highway 71, south of Hosston, is partially closed.
The crash happened some time before 4am, near the intersection of U.S. 71 and St. John's Church Road north of I-49.
An 18-wheeler, carrying assorted freight, was northbound when the driver left the road on the right side and hit several trees.
He died at the scene.
The driver's name is being withheld pending notification of family.
Patrol deputies say only the northbound lane of Hwy. 71 is closed, but drivers are encouraged to take an alternate route to avoid delays while deputies investigate the crash.
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